{"id":3292,"date":"2022-01-12T20:49:40","date_gmt":"2022-01-13T01:49:40","guid":{"rendered":"https:\/\/people.clas.ufl.edu\/boyland\/?page_id=3292"},"modified":"2026-03-19T08:10:24","modified_gmt":"2026-03-19T12:10:24","slug":"youngmin-park","status":"publish","type":"page","link":"https:\/\/people.clas.ufl.edu\/boyland\/youngmin-park\/","title":{"rendered":"Youngmin Park"},"content":{"rendered":"\r\n<section class=\"fullwidth-text-block\">\r\n\t<div class=\"container px-0 pt-5\">\r\n\t\t<div class=\"row align-items-start\">\r\n\t\t\t<div class=\"col-12\">\r\n\t\t\t\t\n<h1 class=\"wp-block-heading\">Youngmin Park<\/h1>\n\n\n\n<h3 class=\"wp-block-heading\">Coarse-Grained Stochastic Model of Myosin-Driven Vesicles into Dendritic Spines<\/h3>\n\n\n\n<p><iframe loading=\"lazy\" title=\"Youngmin Park Colloquium\" width=\"1640\" height=\"923\" src=\"https:\/\/www.youtube.com\/embed\/1Wg-YyKdook?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/p>\n\n\n\n<p>Abstract: We study the dynamics of membrane vesicle motor transport into dendritic spines, which are bulbous intracellular compartments in neurons that play a key role in transmitting signals between neurons. We consider the stochastic analog of the vesicle transport model in [Park and Fai, The Dynamics of Vesicles Driven Into Closed Constrictions by Molecular Motors. Bull. Math. Biol. 82, 141 (2020)]. The stochastic version, which may be considered as an agent-based model, relies mostly on the action of individual myosin motors to produce vesicle motion. To aid in our analysis, we coarse-grain this agent-based model using a master equation combined with a partial differential equation describing the probability of local motor positions. We confirm through convergence studies that the coarse-graining captures the essential features of bistability in velocity (observed in experiments) and waiting-time distributions to switch between steady-state velocities. Interestingly, these results allow us to reformulate the translocation problem in terms of the mean first passage time for a run-and-tumble particle moving on a finite domain with absorbing boundaries at the two ends. We conclude by presenting numerical and analytical calculations of vesicle translocation.<\/p>\n\n\n\r\n\t\t\t<\/div>\r\n\t\t<\/div>\r\n\t<\/div>\r\n<\/section>\r\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":146,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"featured_post":"","footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-3292","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/people.clas.ufl.edu\/boyland\/wp-json\/wp\/v2\/pages\/3292","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/people.clas.ufl.edu\/boyland\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/people.clas.ufl.edu\/boyland\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/people.clas.ufl.edu\/boyland\/wp-json\/wp\/v2\/users\/146"}],"replies":[{"embeddable":true,"href":"https:\/\/people.clas.ufl.edu\/boyland\/wp-json\/wp\/v2\/comments?post=3292"}],"version-history":[{"count":5,"href":"https:\/\/people.clas.ufl.edu\/boyland\/wp-json\/wp\/v2\/pages\/3292\/revisions"}],"predecessor-version":[{"id":3838,"href":"https:\/\/people.clas.ufl.edu\/boyland\/wp-json\/wp\/v2\/pages\/3292\/revisions\/3838"}],"wp:attachment":[{"href":"https:\/\/people.clas.ufl.edu\/boyland\/wp-json\/wp\/v2\/media?parent=3292"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}