{"id":19,"date":"2012-09-05T11:22:25","date_gmt":"2012-09-05T15:22:25","guid":{"rendered":"https:\/\/people.clas.ufl.edu\/template\/?page_id=19"},"modified":"2026-03-19T08:24:59","modified_gmt":"2026-03-19T12:24:59","slug":"publications","status":"publish","type":"page","link":"https:\/\/people.clas.ufl.edu\/knack\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"\r\n
\r\n\t
\r\n\t\t
\r\n\t\t\t
\r\n\t\t\t\t\n

Publications<\/h1>\n\n\n\n

Logan CN (g), Rojas G (ug), Wilkinson CS (g), Polo Escorcia AK (ug), Reichel CM, Peris J,\u00a0Knackstedt LA.<\/strong> (2021). Systemic oxytocin increases glutamate efflux in the nucleus accumbens core of cocaine-experienced male and female rats but only increases dopamine efflux in males.<\/a> Behav Brain Res<\/em>. 417:113590. Online ahead of print.<\/p>\n\n\n\n\n\n

Schwendt M,\u00a0Knackstedt LA.<\/strong> (2021). Extinction vs. Abstinence: A Review of the Molecular and Circuit Consequences of Different Post-Cocaine Experiences.<\/a> Int J Mol Sci<\/em>. 22(11):6113. PMID:\u00a034204090<\/p>\n\n\n\n\n\n

Knackstedt, LA<\/strong>, Wu, L, Rothstein J, Vidensky S, Gordon J, Ramanjulu M, Dunman P, Blass B, Childers W, Abou-Gharbia M. (2021). MC-100093, a novel \u03b2-lactam GLT-1 Enhancer devoid of antimicrobial properties attenuates cocaine relapse in rats<\/a>. Journal of Pharmacol Exp Ther. <\/em>78(2):51-59. PMID: 33986035.<\/p>\n\n\n\n\n\n

\u00a0<\/strong>Shallcross J (g), Wu, L, Knackstedt<\/strong>, LA,<\/strong> Schwendt, M. (2021). Increased mGlu5 mRNA expression in BLA glutamate neurons facilitates resilience to the long- term effects of a single predator scent stress exposure<\/a>. Brain Structure and Function<\/em>. \u00a0226(7):2279-2293. PMID:\u00a034175993<\/p>\n\n\n\n\n\n

Niedzielska-Andres E, Pomierny-Chamio\u0142o L, Andres M, Walczak M, Knackstedt <\/strong>LA,<\/strong> Filip M, Przegali\u0144ski E. (2021). Cocaine Use Disorder: a look at metabotropic glutamate receptors and glutamate transporters<\/a>. Pharmacology & Therapeutics<\/em>. Online ahead of print. PMID: 33359590<\/p>\n\n\n\n\n\n

Griffin WC, Haun HL, Ramachandra VS, Knackstedt LA, <\/strong>Mulholland PJ, Becker HC. (2021). Effects of Ceftriaxone on Ethanol Drinking and GLT-1 Expression in Ethanol Dependence and Relapse Drinking<\/a>. Alcohol<\/em>. Online ahead of print. PMID:\u00a033465464<\/p>\n\n\n\n\n\n

Fischer KD,\u00a0Knackstedt LA<\/strong>, Rosenberg PA. \u00a0(2020). Glutamate homeostasis and dopamine signaling: implications for psychostimulant addiction behavior.<\/a> Neurochem Int. <\/em>Online ahead of print. PMID:\u00a033159978<\/p>\n\n\n\n\n\n

Stennett BA (g),\u00a0Knackstedt LA. <\/strong>(2020). A rat model of cocaine-alcohol polysubstance use reveals altered cocaine seeking and glutamate levels in the nucleus accumbens.<\/a> Front Neurosci<\/em> 14:877. PMID:\u00a032982672<\/p>\n\n\n\n\n\n

Hadad, N (g), Schwendt, M, Knackstedt L.<\/strong> (2020). Hypothalamic-Pituitary-Adrenal Axis Activity in Posttraumatic Stress Disorder and Cocaine Use Disorder<\/a>. Stress.<\/em>\u00a0 23(6):638-650.<\/p>\n\n\n\n\n\n

Smaga I, Fierro D (ug), Mesa J (g), Filip M,\u00a0Knackstedt LA. <\/strong>(2020). Molecular changes evoked by the beta-lactam antibiotic ceftriaxone across rodent models of substance use disorder and neurological disease.<\/a> Neuroscience and Biobehavioral Reviews.<\/em>\u00a0115:116-130.<\/p>\n\n\n\n\n\n

Bechard AR (p), Logan CN (g), Mesa J (g), Hernandez YP (ug), Blount H (ug), Hodges VL (ug), Knackstedt, L <\/strong>(2020).\u00a0 Role of prefrontal cortex projections to the nucleus accumbens core in mediating the effects of ceftriaxone on cued cocaine seeking<\/a>. Addiction Biology <\/em>Online ahead of print.<\/p>\n\n\n\n\n\n

Logan CN (g), Bechard AR (p), Hamor PU (g), Wu L, Schwendt M, Knackstedt LA<\/strong> (2020). Ceftriaxone and mGlu2\/3 interactions in the nucleus accumbens core affect the reinstatement of cocaine-seeking in male and female rats<\/a>. Psychopharmacology<\/em> 237(7): 2007-2018.\u00a0 PMID: 3238278<\/p>\n\n\n\n\n\n

Stennett BA (g), Padovan-Hernandez Y (ug), Knackstedt LA.<\/strong> (2020). Sequential cocaine-alcohol self-administration produces adaptations in rat nucleus accumbens core glutamate homeostasis that are distinct from those produced by cocaine self-administration alone.<\/a> Neuropsychopharmacology<\/em>. 45(3):441-450.<\/p>\n\n\n\n\n\n

Shallcross J (g), H\u00e1mor P, Bechard AR (p), Romano M (ug), Knackstedt L,<\/strong> Schwendt M. (2019). The Divergent Effects of CDPPB and Cannabidiol on Fear Extinction and Anxiety in a Predator Scent Stress Model of PTSD in Rats.<\/a> Front Behav Neurosci.<\/em> 13:91.<\/p>\n\n\n\n\n\n

Bechard, AR (p), Knackstedt, LA.<\/strong> (2019). The effects of Pavlovian cue extinction on cocaine relapse after abstinence. \u00a0Drug and Alcohol Dependence.<\/em> 197:83-86.\u00a0https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30784953<\/a><\/p>\n\n\n\n\n\n

Bechard, AR (p), Hamor P, Wu, L, Schwendt, M, Knackstedt, LA.<\/strong> (2019). The effects of clavulanic acid and amoxicillin on cue-primed reinstatement of cocaine-seeking. \u00a0Behavioral Neuroscience. <\/em>133(2):247-254.\u00a0https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30714803<\/a><\/p>\n\n\n\n\n\n

Schwendt M, Shallcross J (g), Hadad NA(g), Namba M (ug), Hiller H, Wu L, Krause EG, Knackstedt, LA. <\/strong>\u00a0(2018). A novel rat model of comorbid PTSD and addiction reveals intersections between stress susceptibility and enhanced cocaine-seeking with a role for mGlu5 receptors. Translational Psychiatry<\/em>. 8(1): 209.\u00a0https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30291225<\/a><\/p>\n\n\n\n\n\n

Bechard, AR (p), LaCrosse, A (p), Namba, MD (ug), Jackson, B (ug), Knackstedt, LA.<\/strong> (2018). Impairments in reversal learning following short access to cocaine self-administration. Drug and Alcohol Dependence. 192:339-344.\u00a0https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30278419<\/a><\/p>\n\n\n\n\n\n

Yiyang, L, Williamson, V(ug), Setlow, B, Cottler, LB, Knackstedt, LA.<\/strong> The importance of considering polysubstance use; lessons from cocaine research. In press,<\/em> Drug and Alcohol Dependence.\u00a0https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Liu+AND+Knackstedt<\/a><\/p>\n\n\n\n\n\n

Logan CN(g), LaCrosse AL (p), Knackstedt LA. <\/strong>(2018). Nucleus accumbens GLT-1a overexpression reduces glutamate efflux during reinstatement of cocaine-seeking but is not sufficient to attenuate reinstatement. Neuropharmacology<\/em>. 135:297-307. PMID: 29567092. Link<\/a><\/p>\n\n\n\n\n\n

Padovan Hernandez, Y (ug) and Knackstedt LA.<\/strong> (2018). Dose-dependent effects of Clozapine-N-Oxide on cocaine-induced locomotion in rats with a history of cocaine self-administration. Neuroscience Letters<\/em>. 674:132-135. PMID: 29571824. Link\u00a0<\/a><\/p>\n\n\n\n\n\n

Weber RA, Logan, CN(g), Leong, K-C, Peris, J, Knackstedt, L<\/strong>, and Reichel, CM. (2018). Regionally specific effects of oxytocin on reinstatement of cocaine seeking in male and female rats.\u00a0 International Journal of Neuropsychopharmacology, 21(7): 677-686. PMID: 29566161. Link<\/a><\/p>\n\n\n\n\n\n

Bechard A(p), Hamor P(g), Schwendt M, Knackstedt LA. <\/strong>(2018). The estrous cycle influences surface GluA1 expression in the nucleus accumbens and the ability of ceftriaxone to attenuate cue-primed reinstatement of cocaine-seeking. Psychopharmacology, <\/em>235(3):837-848. PMID: 29197981. Link\u00a0<\/a><\/p>\n\n\n\n\n\n

Stennett B, Frankowski, JC, Peris J, and Knackstedt, LA.<\/strong>\u00a0 2017. Ceftriaxone reduces alcohol intake in outbred rats while upregulating xCT in the nucleus accumbens core.\u00a0 Pharmacology, Biochemistry and Behavior<\/em>.\u00a0 159: 18-23. PMID: 28687200\u00a0 Link<\/a><\/p>\n\n\n\n\n\n

Lacrosse AL, O\u2019Donovan S, Sepulveda-Orengo MT, McCullumsmith R, Reissner KJ, Schwendt M, and Knackstedt LA<\/strong>. Contrasting the role of xCT and GLT-1 upregulation in the ability of ceftriaxone to attenuate the reinstatement of cocaine-seeking and normalize AMPA receptor subunit expression. Journal<\/em> of Neuroscience<\/em>,<\/em> 37(24): 5809-5821. PMID: 28495973\u00a0 Link<\/a><\/p>\n\n\n\n\n\n

Hadad NA, Wu L, Hiller H, Krause EG, Schwendt M, Knackstedt LA. <\/strong>(2016). Conditioned stress prevents cue-primed cocaine reinstatement only in stress-responsive rats. Stress, <\/em>19(4):406-18. PMID: 27181613\u00a0 Link<\/a><\/p>\n\n\n\n\n\n

Pati D, Kelly K, Stennett B, Frazier CJ, Knackstedt LA. <\/strong>(2016). Alcohol self-administration increases basal glutamate in the nucleus accumbens of outbred rats without affecting pre-synaptic release properties. European Journal of Neuroscience, <\/em>44(2):1896-1905. PMID: 27207718. Link<\/a><\/p>\n\n\n\n\n\n

Knackstedt LA, Schwendt M. (2016). mGlu5 receptors and relapse to cocaine-seeking: the role of receptor trafficking in post-relapse extinction learning deficits. Neural Plasticity, 2016:9312508. PMID: 26881139 \u00a0Link<\/a><\/p>\n\n\n\n\n\n

Lacrosse AL, Hill K, Knackstedt LA. (2016) Ceftriaxone attenuates cocaine relapse after abstinence through modulation of nucleus accumbens AMPA subunit expression. European Neuropsychopharmacology, 26(2):186-94. PMID: 26706696 \u00a0Link<\/a><\/p>\n\n\n\n\n\n

Massie A, Boillee S, Hewett S, Knackstedt L, Lewerenz J.(2015). System xc- in the central nervous system: a wolf in sheep\u2019s clothing? J Neurochem, 135(6):1062-79. PMID:26336934 \u00a0Link<\/a><\/p>\n\n\n\n\n\n

Griffin, WC, Ramachandra, VS, Knackstedt, LA, Becker, HC. (2015). Repeated cycles of chronic intermittent ethanol exposure increases basal glutamate in the nucleus accumbens of mice without affecting glutamate transport. Frontiers in Pharmacology 6(27). PMID: 25755641 \u00a0 Link<\/a><\/p>\n\n\n\n\n\n

Weiland, A, Garcia. S, Knackstedt, LA. (2015). Cefazolin and ceftriaxone attenuate the cue-primed reinstatement of alcohol-seeking. Frontiers in Pharmacology. 6 (44). PMID:25805996 \u00a0Link<\/a><\/p>\n\n\n\n\n\n

Reissner, K.J., Gipson, C.D, Phuong, K.T., Knackstedt, L.A., Scofield, M.D., Kalivas, P.W. Glutamate transporter GLT-1 mediates N-acetylcysteine inhibition of cocaine reinstatement. Addiction Biology,\u00a020(2): 316-23. PMID:24612076\u00a0 Link<\/a><\/p>\n\n\n\n\n\n

Hadad NA, Knackstedt LA. Addicted to palatable foods: comparing the neurobiology of Bulimia Nervosa to that of drug addiction. Psychopharmacology (Berl), 231(9): 1897-912. PMID:24500676 Link<\/a><\/p>\n\n\n\n\n\n

Knackstedt LA, Trantham-Davidson H, Schwendt M. (2014). The role of ventral and dorsal striatum mGluR5 in relapse to cocaine-seeking and extinction learning. Addiction Biology, 19(1): 87-101. PMID:23710649 Link<\/a><\/p>\n\n\n\n\n\n

Alajaji M, Bowers MS, Knackstedt L, Damaj MI. (2013) Effects of the beta-lactam antibiotic ceftriaxone on nicotine withdrawal and nicotine-induced reinstatement of preference in mice. Psychopharmacology (Berl). 228(3):419-26. PMID: 23503685 Link<\/a><\/p>\n\n\n\n\n\n

Trantham-Davidson H, Lalumiere RT, Reissner KJ, Kalivas PW, Knackstedt LA. (2012). Ceftriaxone Normalizes Nucleus Accumbens Synaptic Transmission, Glutamate Transport, and Export following Cocaine Self-Administration and Extinction Training. Journal of Neuroscience, 32(36):12406-10. PMID:22956831 Link <\/a><\/p>\n\n\n\n\n\n

Wang X, Moussawi K, Knackstedt L, Shen H, Kalivas PW. (2012). Role of mGluR5 neurotransmission in reinstated cocaine-seeking. Addiction Biology, 18(1): 40-9. PMID: 22340009 Link<\/a><\/p>\n\n\n\n\n\n

Sondheimer, I, Knackstedt, L.A. (2011). Ceftriaxone prevents the induction of cocaine sensitization and produces enduring attenuation of cue- and cocaine-primed reinstatement of cocaine-seeking. Behavioural Brain Research, 225(1): 252-258. PMID: 21824497 Link<\/a><\/p>\n\n\n\n\n\n

Uys JD, Knackstedt L, Hurt P, Tew KD, Manevich Y, Hutchens S, Townsend DM, Kalivas PW. (2011). Cocaine Induced Adaptations in Cellular Redox Balance Contributes to Enduring Behavioral Plasticity. Neuropsychopharmacology, 36(12): 2551-60. PMID: 21796101 Link <\/a><\/p>\n\n\n\n\n\n

Knackstedt, LA, Moussawi, K, Lalumiere, R, Schwendt, M, Klugman, M, Kalivas, PW. (2010). Extinction training after cocaine self-administration induces glutamatergic plasticity to inhibit cocaine-seeking. Journal of Neuroscience, 30(23):7984-92. PMID: 2534846. Link <\/a><\/p>\n\n\n\n\n\n

Knackstedt, LA, Melendez, RI, Kalivas, PW. (2010). Ceftriaxone restores glutamate homeostasis and prevents relapse to cocaine seeking. Biological Psychiatry, 67(1): 81-4. PMID: 19717140. Link <\/a><\/p>\n\n\n\n\n\n

Knackstedt, LA, Kalivas, PW. (2009). Glutamate and reinstatement. Current Opinion in Pharmacology, 9(1): 59-64. PMID: 19157986. Link <\/a><\/p>\n\n\n\n\n\n

Knackstedt, LA, Larowe, S, Mardikian, P, Malcolm, R, Upadhaya, H, Hedden, S, Markou, A, Kalivas, PW. (2009). The role of cystine-glutamate exchange in nicotine dependence in rats and humans. Biological Psychiatry, 65(10):841-5. PMID: 19103434 Link <\/a><\/p>\n\n\n\n\n\n

Kalivas, PW, Lalumiere, R, Knackstedt, L, Shen, HW. (2008). Glutamate transmission in addiction. Neuropharmacology, 56 Suppl 1:169-73. PMID: 18675832. Link <\/a><\/p>\n\n\n\n\n\n

Knackstedt LA, Kalivas PW. (2007). Extended-access to cocaine self-administration enhances drug-primed reinstatement but not behavioral sensitization. J Pharmacol Exper Ther 322(3): 1103-09. PMID: 17601982. Link <\/a><\/p>\n\n\n\n\n\n

Knackstedt LA, Ettenberg A. (2006). Alcohol consumption is preferred to water in animals pretreated with cocaine. Pharmacol Biochem Behav 85: 281-86. PMID: 17049976. Link<\/a><\/p>\n\n\n\n\n\n

Kalivas PW, Peters J, Knackstedt LA. (2006). Animal models and brain circuits in drug addiction. Mol Intervent 6(6): 339-44. PMID: 17200461. Link<\/a><\/p>\n\n\n\n\n\n

Knackstedt LA, Kalivas PW. (2006). Pharmacotherapy targets for regulating cocaine-induced plasticity. Drugs of the Future, 31(10): 893-912, 2006.<\/p>\n\n\n\n\n\n

Knackstedt LA, Ettenberg A. (2004). Ethanol consumption reduces the adverse consequences of self-administered intravenous cocaine in rats. Psychopharmacology, 178: 143-50. PMID: 15338105. Link<\/a><\/p>\n\n\n\n\n\n

Knackstedt LA, Samimi MM, Ettenberg A. (2002). Evidence for the opponent-process actions of intravenous cocaine and cocaethylene. Pharmacology Biochemistry Behavior 72: 931-36. PMID: 12062583 Link<\/a><\/p>\n\n\n\r\n\t\t\t<\/div>\r\n\t\t<\/div>\r\n\t<\/div>\r\n<\/section>\r\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":11,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"featured_post":"","footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-19","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/people.clas.ufl.edu\/knack\/wp-json\/wp\/v2\/pages\/19","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/people.clas.ufl.edu\/knack\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/people.clas.ufl.edu\/knack\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/people.clas.ufl.edu\/knack\/wp-json\/wp\/v2\/users\/11"}],"replies":[{"embeddable":true,"href":"https:\/\/people.clas.ufl.edu\/knack\/wp-json\/wp\/v2\/comments?post=19"}],"version-history":[{"count":11,"href":"https:\/\/people.clas.ufl.edu\/knack\/wp-json\/wp\/v2\/pages\/19\/revisions"}],"predecessor-version":[{"id":299,"href":"https:\/\/people.clas.ufl.edu\/knack\/wp-json\/wp\/v2\/pages\/19\/revisions\/299"}],"wp:attachment":[{"href":"https:\/\/people.clas.ufl.edu\/knack\/wp-json\/wp\/v2\/media?parent=19"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}