Publications

Stennett B, Frankowski, JC, Peris J, and Knackstedt, LA.  2017. Ceftriaxone reduces alcohol intake in outbred rats while upregulating xCT in the nucleus accumbens core.  Pharmacology, Biochemistry and Behavior.  159: 18-23. PMID: 28687200  Link

Lacrosse AL, O’Donovan S, Sepulveda-Orengo MT, McCullumsmith R, Reissner KJ, Schwendt M, and Knackstedt LA. Contrasting the role of xCT and GLT-1 upregulation in the ability of ceftriaxone to attenuate the reinstatement of cocaine-seeking and normalize AMPA receptor subunit expression. Journal of Neuroscience, 37(24): 5809-5821. PMID: 28495973  Link

Hadad NA, Wu L, Hiller H, Krause EG, Schwendt M, Knackstedt LA. (2016). Conditioned stress prevents cue-primed cocaine reinstatement only in stress-responsive rats. Stress, 19(4):406-18. PMID: 27181613  Link

Pati D, Kelly K, Stennett B, Frazier CJ, Knackstedt LA. (2016). Alcohol self-administration increases basal glutamate in the nucleus accumbens of outbred rats without affecting pre-synaptic release properties. European Journal of Neuroscience, 44(2):1896-1905. PMID: 27207718. Link

Knackstedt LA, Schwendt M. (2016). mGlu5 receptors and relapse to cocaine-seeking: the role of receptor trafficking in post-relapse extinction learning deficits. Neural Plasticity, 2016:9312508. PMID: 26881139  Link

Lacrosse AL, Hill K, Knackstedt LA. (2016) Ceftriaxone attenuates cocaine relapse after abstinence through modulation of nucleus accumbens AMPA subunit expression. European Neuropsychopharmacology, 26(2):186-94. PMID: 26706696  Link

Massie A, Boillee S, Hewett S, Knackstedt L, Lewerenz J.(2015). System xc- in the central nervous system: a wolf in sheep’s clothing? J Neurochem, 135(6):1062-79. PMID:26336934  Link

Griffin, WC, Ramachandra, VS, Knackstedt, LA, Becker, HC. (2015). Repeated cycles of chronic intermittent ethanol exposure increases basal glutamate in the nucleus accumbens of mice without affecting glutamate transport. Frontiers in Pharmacology 6(27). PMID: 25755641   Link

Weiland, A, Garcia. S, Knackstedt, LA. (2015). Cefazolin and ceftriaxone attenuate the cue-primed reinstatement of alcohol-seeking. Frontiers in Pharmacology. 6 (44). PMID:25805996  Link

Reissner, K.J., Gipson, C.D, Phuong, K.T., Knackstedt, L.A., Scofield, M.D., Kalivas, P.W. Glutamate transporter GLT-1 mediates N-acetylcysteine inhibition of cocaine reinstatement. Addiction Biology, 20(2): 316-23. PMID:24612076  Link

Hadad NA, Knackstedt LA. Addicted to palatable foods: comparing the neurobiology of Bulimia Nervosa to that of drug addiction. Psychopharmacology (Berl), 231(9): 1897-912. PMID:24500676 Link

Knackstedt LA, Trantham-Davidson H, Schwendt M. (2014). The role of ventral and dorsal striatum mGluR5 in relapse to cocaine-seeking and extinction learning. Addiction Biology, 19(1): 87-101. PMID:23710649 Link

Alajaji M, Bowers MS, Knackstedt L, Damaj MI. (2013) Effects of the beta-lactam antibiotic ceftriaxone on nicotine withdrawal and nicotine-induced reinstatement of preference in mice. Psychopharmacology (Berl). 228(3):419-26. PMID: 23503685 Link

Trantham-Davidson H, Lalumiere RT, Reissner KJ, Kalivas PW, Knackstedt LA. (2012). Ceftriaxone Normalizes Nucleus Accumbens Synaptic Transmission, Glutamate Transport, and Export following Cocaine Self-Administration and Extinction Training. Journal of Neuroscience, 32(36):12406-10. PMID:22956831 Link

Wang X, Moussawi K, Knackstedt L, Shen H, Kalivas PW. (2012). Role of mGluR5 neurotransmission in reinstated cocaine-seeking. Addiction Biology, 18(1): 40-9. PMID: 22340009 Link

Sondheimer, I, Knackstedt, L.A. (2011). Ceftriaxone prevents the induction of cocaine sensitization and produces enduring attenuation of cue- and cocaine-primed reinstatement of cocaine-seeking. Behavioural Brain Research, 225(1): 252-258. PMID: 21824497 Link

Uys JD, Knackstedt L, Hurt P, Tew KD, Manevich Y, Hutchens S, Townsend DM, Kalivas PW. (2011). Cocaine Induced Adaptations in Cellular Redox Balance Contributes to Enduring Behavioral Plasticity. Neuropsychopharmacology, 36(12): 2551-60. PMID: 21796101 Link

Knackstedt, LA, Moussawi, K, Lalumiere, R, Schwendt, M, Klugman, M, Kalivas, PW. (2010). Extinction training after cocaine self-administration induces glutamatergic plasticity to inhibit cocaine-seeking. Journal of Neuroscience, 30(23):7984-92. PMID: 2534846. Link

Knackstedt, LA, Melendez, RI, Kalivas, PW. (2010). Ceftriaxone restores glutamate homeostasis and prevents relapse to cocaine seeking. Biological Psychiatry, 67(1): 81-4. PMID: 19717140. Link

Knackstedt, LA, Kalivas, PW. (2009). Glutamate and reinstatement. Current Opinion in Pharmacology, 9(1): 59-64. PMID: 19157986. Link

Knackstedt, LA, Larowe, S, Mardikian, P, Malcolm, R, Upadhaya, H, Hedden, S, Markou, A, Kalivas, PW. (2009). The role of cystine-glutamate exchange in nicotine dependence in rats and humans. Biological Psychiatry, 65(10):841-5. PMID: 19103434 Link

Kalivas, PW, Lalumiere, R, Knackstedt, L, Shen, HW. (2008). Glutamate transmission in addiction. Neuropharmacology, 56 Suppl 1:169-73. PMID: 18675832. Link

Knackstedt LA, Kalivas PW. (2007). Extended-access to cocaine self-administration enhances drug-primed reinstatement but not behavioral sensitization. J Pharmacol Exper Ther 322(3): 1103-09. PMID: 17601982. Link

Knackstedt LA, Ettenberg A. (2006). Alcohol consumption is preferred to water in animals pretreated with cocaine. Pharmacol Biochem Behav 85: 281-86. PMID: 17049976. Link

Kalivas PW, Peters J, Knackstedt LA. (2006). Animal models and brain circuits in drug addiction. Mol Intervent 6(6): 339-44. PMID: 17200461. Link

Knackstedt LA, Kalivas PW. (2006). Pharmacotherapy targets for regulating cocaine-induced plasticity. Drugs of the Future, 31(10): 893-912, 2006.

Knackstedt LA, Ettenberg A. (2004). Ethanol consumption reduces the adverse consequences of self-administered intravenous cocaine in rats. Psychopharmacology, 178: 143-50. PMID: 15338105. Link

Knackstedt LA, Samimi MM, Ettenberg A. (2002). Evidence for the opponent-process actions of intravenous cocaine and cocaethylene. Pharmacology Biochemistry Behavior 72: 931-36. PMID: 12062583 Link